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Journal of Applied Gerontology
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Relationship of Medication Use to Health-Related Quality of Life Among a Group of Older American Indians

Jeffrey A. Henderson

University of Colorado

Dedra Buchwald

University of Washington, University of Colorado

Spero M. Manson

University of Colorado

This cross-sectional study examines the relationship of polypharmacy to health-related quality of life (HRQoL) among a group of older American Indians. An in-home interview and survey were administered to 63 community-dwelling American Indians aged 50 or older who were taking four or more prescription medications regularly. With the component summary scores from the Medical Outcomes Study Short Form-36 instrument analyzed as dependent variables, only the Physical Component Summary (PCS) score (r = .30, p = .02), and not the Mental (r = .06, p = .67), was associated with degree of polypharmacy. This association with PCS score remained significant even after controlling for age, sex, and chronic disease score (adjusted ß = -.91, p = .045). This study is the first to describe the relationship between polypharmacy and HRQoL among a group of American Indians, and the results support the need for larger and more comprehensive studies of medication use in this special population.

Key Words: American Indian aging • prescription drugs • polypharmacy • quality of life • health status

Journal of Applied Gerontology, Vol. 25, No. 1 suppl, 89S-104S (2006)
DOI: 10.1177/0733464805283035
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